|Why Pregnenolone is
Critically Important to Good Health
One of Gary Young's booklets, Pregnenolone: A Radical New
Approach to Health, Longevity, and Emotional Well-Being, is a
compilation of exciting research on this little-known hormone
precursor. As the book explains, pregnenolone is made from cholesterol
in the body; and in turn, pregnenolone can be synthesized into a number
of hormones: estrogen, progesterone, testosterone, DHEA, aldosterone,
cortisol, etc. Pregnenolone is the master hormone from which all the
steroid hormones are derived.
One reason that most people have not heard much about pregnenolone
has to do with drug companies and profits. Gary Young told how
pregnenolone research in the early 1940s was very promising and showed
pregnenolone is effective in relieving arthritis pain, reducing PMS and
menopausal symptoms, fighting stress and fatigue, improving memory, and
lifting mood. But just as this research was being printed in medical
journals, the discovery of synthetic cortisone was announced.
Cortisone showed powerful and immediate effectiveness against
arthritis. Drug companies could patent their laboratory version of
cortisone and make a huge profit. Pregnenolone is a natural substance
and not patentable. Because synthetic cortisone was so fast-acting and
offered great profit potential, pregnenolone research was basically
It was not discovered until later that synthetic cortisone had
terrifying side-effects (immune system suppression and osteoporosis
being the two most devastating). Pregnenolone has been shown to be
virtually free of side effects. A man in one pregnenolone study did
develop a temporary rash; while in another study on memory, a
participant reported the "side effect" of decreased symptoms of
The beneficial effects of pregnenolone on arthritis and other bone,
joint, and muscle diseases are well documented. In two studies on
ankylosing spondylitis -- an inflammatory disease of the joints that
causes back pain and stiffening -- patients showed marked improvement
when treated with pregnenolone.1
Neurobiologist Dr. Eugene Roberts studied the arthritis research from
the 1940s and 1950s and said: "Treatment with PREG can be maintained
indefinitely without apparent harmful effects and is much less expensive
than with ACTH or cortisone or with other anti-inflammatory steroids."2
Scientists and researchers are again looking at the value of
pregnenolone. The research that Gary Young found establishes how
pregnenolone declines in the body more than 60 percent between the ages
of 35 and 75. Along with this natural bodily decline, our bodies have
had to deal with a decrease in the building block of pregnenolone:
cholesterol. "Low-cholesterol" or "no-cholesterol" has been pounded into
the heads of health-conscious consumers. While the cholesterol link to
heart disease is under question today, cholesterol-lowering drugs are
causing a hormone imbalance. Without cholesterol there is no
pregnenolone, which in turn creates hormones.
The lack of cholesterol (and thus pregnenolone) in our diets may be
the cause of many cases of depression. Dr. William Regelson writes that
"a recent study conducted by the National Institutes of Mental health
showed that people with depression have lower than normal amounts of
pregnenolone in their cerebral spinal fluid (the fluid that bathes the
Spinal cord injuries may be minimized with pregenolone according to a
number of rat studies. Dr. Eugene Roberts, would like to see a
pregnenolone cream placed in first aid kits for use on the spine
following earthquakes or accidents.4
Menopause is a dreaded ordeal for millions of women who choose not to
use estrogen replacement therapy because of a four to eight times higher
incidence of uterine cancer. The pharmaceutical companies came up with
"hormone replacement therapy" where they combine synthetic progesterone
with conjugated equine estrogen. The majority of female consumers of
this therapy are probably unaware that the estrogen they are taking is
not natural to the human body and comes from pregnant mare's urine (PMU).
Dr. John R. Lee, notes that 52 percent of the estrogens in this
concoction are the horse estrogens equilin and equilenin which are not
natural to humans.5
Gary Young talked about how the synthetic estrogens and progesterones
"plug" the body's receptor sites. "All of your prescription drugs are
based on petrochemicals and these chemicals plug receptor sites creating
even a greater imbalance, and suppressing and compromising immune
function." He explained the value of the Raindrop Technique where
certain oils are dropped along the spine. "Along the spine happens to be
one of the largest accumulations of receptor nerve sites, and that's why
Raindrop Technique works so specifically. When the oils get in there and
can start stimulating nerve transmission, that's very, very important.
When you put the oils with pregnenolone, then they carry the
pregnenolone into the cell structure to start that cell's rejuvenation.
It is win, win, win and balance, balance, balance," Gary said.
Wouldn't it make more sense to use a natural substance in hormone
replacement therapy? The best thing about pregnenolone is that it is
completely natural. The human body, the true "master chemist,"
transforms pregnenolone into the hormones the body is lacking. Estrogen,
progesterone, or testosterone -- it all depends on what is needed most.
Men are also susceptible to the age-related loss of pregnenolone in
the body. They needn't fear that pregnenolone might be turned into a
female hormone. Research on memory by Rahmawhati Sih, Ph.D., showed that
after older men and women were given pregnenolone, the memory tests that
were given three hours later showed gender variation. The women rated
higher in verbal recall while men improved in visual spatial tasks that
required three-dimensional thinking. Dr. William Regelson reviewed this
research in his book The Super Hormone Promise: Nature's Antidote to
Aging and wrote that Dr. Sih's "results suggest that pregnenolone is
being broken down differently in men and women; that is, it appears to
have a testosterone-like effect in men and an estrogen-like effect in
The book Pregnenolone: A Radical New Approach to Health,
Longevity, and Emotional Well-Being is available at Essential
Science Publishing Company.
YOUNG LIVING PRODUCTS WITH
Progessence Cream #3725
Regenolone Cream #3729
Prenolone Cream #3731 (w/o DHEA)
Prenolone Plus Cream #3732(w /DHEA)
1. Sahelian, Ray, M.D. Pregnenolone: Nature's Feel Good Hormone.
(Garden City Park, New York: Avery Publishing Group, 1997), 57.
2. Roberts, E. "Pregnenolone -- From Selye to Alzheimer and a Model
of the Pregnenolone Sulfate Binding Site on the GABA A Receptor,"
Biochemical Pharmacology 49:1 (1995): 1-16.
3. Regelson, William, MD, and Carol Colman. The Super-Hormone
Promise: Nature's Antidote to Aging. (New York: Pocket Books, 1996),
4. Young, D. Gary, N.D. Pregnenolone: A Radical New Approach to
Health, Longevity, and Emotional Well-being. (Salem, Utah: Essential
Science Publishing, 2000), 21.
5. Lee, John R., MD "Natural" vs. "Synthetic" Hormones, a Question
of Semantics. [http://home.coqui.net/ytorres/NHRT/art,11.htm] (3
6. Regelson, 77.